Letters written by Julia Rush, wife of Benjamin Rush, mainly to her husband, with one to Samuel Stockton and one to Mary Rush. Eight letters were written during the 1793 yellow fever epidemic. The letters are not included in Lyman Butterfield's edition of Benjamin Rush's letters, vol. 30 of APS Memoirs (1951).

Sarah Franklin Bache (1743-1808), a Revolutionary War patriot and daughter of Benjamin Franklin, led an active public life according to the standards of womanhood in the late eighteenth century. As the daughter of Benjamin Franklin she had an unusual access, for a woman, to the political life in revolutionary Philadelphia. Although her primary role was of caretaker of her family and home, Bache played an active role in the Revolution through her relief work and as her father's political hostess. The Sarah Franklin Bache papers consist of incoming and outgoing correspondence ranging from 1768 to 1807 mostly of a personal nature to and from friends and relatives. The correspondence of her relatives includes her nephew William Temple Franklin, her brother William Franklin and her children.

The collection contains information on Fox family speculation in western lands, two manuscript maps from the 1790's and 1830's depicting the family's holdings in northwestern Pennsylvania, and a photograph album from the 1890's documenting Chestnutwold, the Fox estate adjacent to Andalusia. Chief correspondents are Samuel and George Fox.

This autobiography relates Rush's experiences in college and medical school; his meetings with notable doctors; his life in Scotland, England, and France; his medical views; the military and politics during the Revolutionary War; and brief sketches of personalities of that period.

The collection includes letters between Hutchinson and his uncle Israel Pemberton, written while Hutchinson was a student of medicine in London. There are also 12 tickets of admission to medical lectures in Philadelphia and London, including one given by William Hunter, and 3 unused cards of admission to Hutchinson's own lectures. Miscellaneous items include Hutchinson's marriage certificate; genealogical data on the Hutchinson, Hare, and Pemberton families; and stock certificates, 1857-1872, of the McKean and Elk Land and Improvement Company. Materials dated post-1793 are to and from Hutchinson family members.